Subsequently, V D/V T was calculated using four methods: Enghoff-DBag, Enghoff-InCal, Enghoff-VCap, and Bohr-VCap. PeCO 2 was measured in expired air using three techniques: Douglas bag (DBag), indirect calorimetry (InCal), and VCap. PACO 2 was measured using VCap to calculate Bohr dead space or substituted with partial pressure of carbon dioxide in arterial blood (PaCO 2) to calculate the Enghoff modification. In a prospective, observational study, 15 post-cardiac surgery patients and 15 patients with ARDS were included. The purpose of the present study was to evaluate how VCap and other available techniques to measure PACO 2 and partial pressure of carbon dioxide in mixed expired air (PeCO 2) affect calculated V D/V T. Recently, a novel technique to calculate partial pressure of carbon dioxide in alveolar air (PACO 2) using volumetric capnography (VCap) was validated. However, V D/V T is rarely calculated in clinical practice, because its measurement is perceived as challenging. In patients with acute respiratory distress syndrome (ARDS), V D/V T has prognostic value and can be used to guide ventilator settings. 45: 227–243.Physiological dead space (V D/V T) represents the fraction of ventilation not participating in gas exchange. The physiologic basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases. Philadelphia: Lippincott Williams & Wilkins. In: Lippincott's Pathophysiology Series: Pulmonary Pathophysiology. “Gas transport to and from peripheral tissues”. In: Fishman's Pulmonary Diseases and Disorders, edited by MA, Grippi (editor-in-chief), JA, Elias, JA, Fishman, RM, Kotloff, AI, Pack, RM, Senior (editors). “Clinical presentations: gas exchange and transport”.
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